REVIEW ON POTENTIAL TARGETED THERAPY FOR TRIPLE NEGATIVE BREAST CANCER

  • Nurul Issttifa Aminuddin 1Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia.
  • Raihana Edros 1Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia.
  • Rajaletchumy Veloo Kutty 1Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang, 26300 Gambang, Pahang, Malaysia and 2Center of Excellence for Advanced Research in Fluid Flow, Universiti Malaysia Pahang, 26300 Gambnag, Pahang, Malaysia.
Keywords: Targeted therapies, triple negative breast cancer

Abstract

Triple negative breast cancer (TNBC) is a very aggressive type of cancer.  TNBC is not just a single type of disease to be cured, but it consists of 6 subtypes which are basal-like 1 and 2, immunomodulatory, mesenchymal, mesenchymal stem- like and luminar androgen receptor. These subtypes has diverse characteristics, which hold potential opportunity for targeted treatment. Lack of molecular targets for triple negative tumor lead to limited targeted therapies for TNBC.  Therefore, effective targeted therapies are urgently needed for TNBC. This paper will highlight on the potential targets in TNBC and treatment options that are currently under clinical application.

 

Published
2020-04-08
Section
Articles